姓名：李西宇

职称：研究员

所在学系：口腔基础医学系

研究生导师类别：硕导

联系方式：lixiyu@scu.edu.cn

研究领域：牙/骨组织再生新材料及多模态示踪

个人简介

四川大学华西口腔医学院研究员、硕导，口腔基础医学系副主任。长期致力于解决感染控制和组织再生难题，专注于牙/骨组织再生新材料及多模态示踪技术。主要研究：1）创新材料开发与功能集成：成功开发集荧光、CT、MRI等多示踪特性于一体的纳米磷灰石晶体，并构建抗菌-成骨-多模态示踪协同功能材料，为感染性骨缺损修复提供新方案。2）再生机制深度解析与可视化：深入探究材料-生物相互作用机制，揭示HA晶体与成骨细胞、骨连蛋白协同促进骨再生，并通过荧光示踪实现骨修复过程可视化监测。3）多功能生物材料应用拓展：构建pH智能响应型皮肤贴片，通过时空调控实现杀菌抗炎，促进创口愈合。以第一作者或通讯作者在Science Advances、Small、Bioactive Materials等国际知名期刊发表多篇高水平论文，获5项中国发明专利授权。主持国家自然科学基金（青年及面上项目）、国家重点研发计划子课题、四川省杰出青年科学基金和四川省重点研发项目。荣获四川省杰青、天府青城计划青年科技人才、中华口腔医学会“口腔医学青年科学家论坛”最具潜力奖、四川省海外高层次留学人才、四川大学好未来教学名师奖、学术新人奖、双百B人才。担任中华口腔医学会材料专业委员会委员、四川省口腔医学会口腔材料专业委员会常务委员。

代表性论文/著作

1.Xiyu Li; Qin Zou*; Haifeng Chen; Wei Li*, In Vivo Changes of Nanoapatite Crystals during Bone Reconstruction and The Differences with Native Bone Apatite. Science Advances 2019, 5 (11), eaay6484. 

2. Xiyu Li; Qin Zou*; Yi Man; Wei Li*, Synergistic Effects of Novel Superparamagnetic/Upconversion HA Material and Ti/Magnet Implant on Biological Performance and Long-Term in Vivo Tracking. Small 2019, 15 (31), 1901617. 

3. Wei Yang; Qin Zou; Chenxin Wang; Yuankun Ren; Rui Zhang; Mingyue Lin; Zeyu Huang; Mengxin Huangfu; Lili Lin; Wei Li; Xiyu Li*, Enhancing Bone Regeneration and Osteogenic Quality by n-HA Internalized Osteoblasts Synergized with ON Protein: Mechanistic Insights. ACS Applied Materials & Interfaces 2024, 16 (50), 68967-68982.

4. Mengxin Huangfu#; Yuankun Ren#; Wei Yang; Yu Liu; Xiyu Li*, pH-Responsive Bilayer Hydrogel with Synergistic Antibacterial/Anti-inflammatory Effect for Infected Wound Healing. ACS Applied Materials & Interfaces 2025, 17 (28), 40258-40275.

5. Mengqin Gu; Linglin Zhang; Liying Hao; Kun Wang; Wei Yang; Zhenqi Liu; Zixue Lei; Yinmo Zhang; Wei Li; Li Jiang*; Xiyu Li*, Upconversion Nanoplatform Enables Multimodal Imaging and Combinatorial Immunotherapy for Synergistic Tumor Treatment and Monitoring. ACS Applied Materials & Interfaces 2023, 15 (18), 21766-21780. 

6. Xiyu Li; Juan Wu; Danxue Li; Qin Zou*; Yi Man; Ling Zou; Wei Li*, Pro-Osteogenesis and in Vivo Tracking Investigation of a Dental Implantation System Comprising Novel mTi Implant and HYH-Fe Particles. Bioactive Materials 2021, 6 (9), 2658-2666. 

7. Xiyu Li; Qin Zou*; Jiawei Wei; Wei Li*, The Degradation Regulation of 3D Printed Scaffolds for Promotion of Osteogenesis and in Vivo Tracking. Composites Part B: Engineering 2021, 222, 109084.

8. Mengqin Gu; Wei Li; Li Jiang*; Xiyu Li*, Recent Progress of Rare Earth Doped Hydroxyapatite Nanoparticles: Luminescence Properties, Synthesis and Biomedical Applications. Acta Biomaterialia 2022, 148, 22-43. 

9. Juan Wu#; Yaqi Chi#; Yujia Yan; Mengzhen Ji; Xuan Chen; Xueqin Yang; Yuan Gao; Qin Zou; Ling Zou*; Xiyu Li*, Investigation of the Antibacterial Effect, Osteogenic Activity, and Tracing Properties of Hydroxyapatite Co-Doped with Tb3+ and Zn2+. Nanoscale 2023, 15 (8), 3940-3951. 

10. Mengqin Gu#; Li Jiang#; Liying Hao; Junzhuo Lu; Zhenqi Liu; Zixue Lei; Yijun Li; Chengge Hua; Wei Li*; Xiyu Li*, A Novel Theranostic Nanoplatform for Imaging-Guided Chemo-Photothermal Therapy in Oral Squamous Cell Carcinoma. Journal of Materials Chemistry B 2021, 9 (30), 6006-6016.

其他

https://www.researchgate.net/profile/Xiyu-Li-4?ev=hdr_xprf